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href="../../page/18946/personal-engagement.html">Personal engagement</a></li><li><a href="../../page/18950/exploration.html">Exploration</a></li><li><a href="../../page/18957/analysis.html">Analysis</a></li><li><a href="../../page/18965/evaluation.html">Evaluation</a></li><li><a href="../../page/18966/communication.html">Communication</a></li><li><a href="../../page/19882/internal-standardization-of-the-ia.html">Internal standardization of the IA</a></li><li><a href="../../page/19901/submitting-the-samples-for-moderation.html">Submitting the samples for moderation</a></li><li><a href="../../page/33754/ten-suggestions-for-ias-using-secondary-data.html">Ten suggestions for IAs using secondary data</a></li><li><a href="../../page/37544/gaining-full-marks-for-a-databased-ia-.html">Gaining full marks for a databased IA </a></li><li><a href="../../page/19506/ia-example-marking-exercise-.html">IA example & marking exercise </a></li><li><a href="../../page/23929/genuine-examples-of-moderated-ia-reports.html">Genuine examples of moderated IA reports</a></li><li><a href="../../page/25234/examples-of-teacher-marked-ia-reports-.html">Examples of teacher-marked IA reports </a></li><li><a href="../../page/37542/history-of-internal-assessment.html">History of Internal Assessment</a></li></ul></li><li><a href="../../page/16598/mandatory-laboratory-components.html" class="father">Mandatory laboratory components</a><ul class="level-2"><li><a href="../../page/16613/formula-of-magnesium-oxide-.html">Formula of magnesium oxide </a></li><li><a href="../../page/16612/determining-the-mr-of-an-unknown-gas.html">Determining the <i>M</i><sub>r</sub> of an unknown gas</a></li><li><a href="../../page/16615/acid-base-titrations-.html">Acid-base titrations </a></li><li><a href="../../page/16616/a-green-acid-base-practical.html">A green acid-base practical</a></li><li><a href="../../page/16617/analysis-of-aspirin-tablets.html">Analysis of aspirin tablets</a></li><li><a href="../../page/16618/caco3-in-egg-shells.html">CaCO<sub>3</sub> in egg shells</a></li><li><a href="../../page/16644/enthalpy-changes.html">Enthalpy changes</a></li><li><a href="../../page/16631/reaction-rates.html">Reaction rates</a></li><li><a href="../../page/16635/rate-dependent-factors.html">Rate-dependent factors</a></li><li><a href="../../page/16636/determining-ea-for-a-reaction.html">Determining <i>E</i><sub>a</sub> for a reaction</a></li><li><a href="../../page/16637/iodination-of-propanone.html">Iodination of propanone</a></li><li><a href="../../page/18144/titrations-with-a-ph-meter.html">Titrations with a pH meter</a></li><li><a href="../../page/18355/redox-titration-with-kmno4-.html">Redox titration with KMnO<sub>4</sub> </a></li><li><a href="../../page/16640/voltaic-cells.html">Voltaic cells</a></li><li><a href="../../page/16659/3-d-molecular-modelling-.html">3-D molecular modelling </a></li></ul></li><li><a href="../../page/17168/other-good-practicals.html" class="father">Other good practicals</a><ul class="level-2"><li><a href="../../page/17196/common-chemical-reactions.html">Common chemical reactions</a></li><li><a href="../../page/227/elements-oxides-of-the-third-period-.html">Elements & oxides of the third period </a></li><li><a href="../../page/17239/the-halogens.html">The halogens</a></li><li><a href="../../page/17162/boiling-points-of-mixtures.html">Boiling points of mixtures</a></li><li><a href="../../page/17170/polarity-of-molecules.html">Polarity of molecules</a></li><li><a href="../../page/18083/le-chateliers-principle-.html">Le Chatelier&#039;s principle </a></li><li><a href="../../page/19582/determining-kc-for-an-esterification-reaction.html">Determining <i>K</i><sub>c</sub> for an esterification reaction</a></li><li><a href="../../page/18164/redox-reactions-of-vanadium-.html">Redox reactions of vanadium </a></li><li><a href="../../page/18351/chlorine-in-swimming-pools-.html">Chlorine in swimming pools </a></li><li><a href="../../page/18178/analysis-of-cuii-ions-in-solution-.html">Analysis of Cu(II) ions in solution </a></li><li><a href="../../page/18179/percentage-of-copper-in-brass.html">Percentage of copper in brass</a></li><li><a href="../../page/18356/electrolytic-cells-.html">Electrolytic cells </a></li><li><a href="../../page/18598/reactions-of-organic-compounds.html">Reactions of organic compounds</a></li><li><a href="../../page/18752/hydrolysis-of-halogenoalkanes.html">Hydrolysis of halogenoalkanes</a></li><li><a href="../../page/18784/preparation-of-13-dinitrobenzene-.html">Preparation of 1,3-dinitrobenzene </a></li><li><a href="../../page/19022/determination-of-an-organic-structure.html">Determination of an organic structure</a></li><li><a href="../../page/19887/preparation-of-nylon-66.html">Preparation of nylon 6,6</a></li><li><a href="../../page/19343/determination-of-vitamin-c-content-.html">Determination of vitamin C content </a></li><li><a href="../../page/19342/hydrolysis-of-starch-.html">Hydrolysis of starch </a></li><li><a href="../../page/19159/preparation-purification-of-aspirin-.html">Preparation & purification of aspirin </a></li></ul></li><li><a href="../../page/18851/ict-in-practical-work.html" class="father">ICT in practical work</a><ul class="level-2"><li><a href="../../page/18852/data-logging-.html">Data logging </a></li><li><a href="../../page/18853/software-for-graph-plotting-.html">Software for graph plotting </a></li><li><a href="../../page/18854/spreadsheets-for-data-processing-.html">Spreadsheets for data processing </a></li><li><a href="../../page/18855/databases.html">Databases</a></li><li><a href="../../page/18856/computer-modelling-simulations-.html">Computer modelling & simulations </a></li></ul></li><li><a href="../../page/16594/group-4-project.html" class="father">Group 4 Project</a><ul class="level-2"><li><a href="../../page/16595/practicalities.html">Practicalities</a></li><li><a href="../../page/16596/reflective-statement-.html">Reflective statement </a></li></ul></li><li><a href="../../page/16666/a-new-laboratory.html">A new laboratory?</a></li></ul></li><li><a href="../../page/16284/exams.html">Exams</a><ul class="level-1"><li><a href="../../page/16286/essential-facts.html" class="father">Essential Facts</a><ul class="level-2"><li><a href="../../page/16287/objectives-command-terms.html">Objectives & command terms</a></li><li><a href="../../page/16288/grade-descriptors.html">Grade descriptors</a></li><li><a href="../../page/16289/grade-boundaries.html">Grade boundaries</a></li></ul></li><li><a href="../../page/16302/paper-1-multiple-choice.html" class="father">Paper 1 (Multiple Choice)</a><ul class="level-2"><li><a href="../../page/16303/advice-to-students-paper-1.html">Advice to students (Paper 1)</a></li><li><a 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            <h1 class="section-title">Sales of Zantac<sup>®</sup> suspended</h1>
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                Sunday 29 September 2019
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                <div style="padding: 0 30px;"><p style="text-align: center;"><img alt="" class="noborder" src="../../../ib/chemistry/images/2014-blog/zantac-1.jpg" style="width: 450px; height: 450px;"></p><p style="text-align: center;">Zantac is one of the most widely used H2 receptor blocker antacids</p><hr class="hidden"><p>A few weeks ago <a href="../30054/the-danger-of-prolonged-use-of-proton-pump-inhibitors-.html">I wrote about the dangers of taking PPIs long term,</a> now it is H2 receptor blockers that are coming under the spotlight. Both PPIs and H2 receptor blockers are among the most widely taken drugs worldwide and both are taken to combat heartburn and indigestion, i.e. as antacids. Along with the more traditional neutralising antacids, such as magnesium hydroxide, both PPIs (proton pump inhibitors) and H2 receptor blockers are covered under&nbsp;<a href="../../page/19184/ph-regulation-of-the-stomach.html" title="Options » Option D » pH regulation of the stomach">D.4: pH regulation of the stomach</a> in option D: Medicinal chemistry. The long term and short term side-effects of drugs are also covered under Option D.</p><p>Long term use of PPIs, such as omeprazole and esomeprazole, has been shown to lead to an increase in death due to an increase in cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer. Today (29 September 2019) several news agencies, e.g. <a href="https://www.reuters.com/article/us-cvs-health-heartburn/cvs-suspends-sales-of-zantac-brand-and-generic-heartburn-drug-during-safety-review-idUSKBN1WD0P0">Reuters</a>, <a href="https://www.bbc.com/news/health-49868852">The BBC</a> and <a href="https://6abc.com/health/cvs-suspends-sale-of-zantac-heartburn-medication-over-cancer-fears/5575940/">ABC news</a> have just announced that one of the big US retailers of drugs and medicines has suspended the sale of Zantac, the most popular H2 receptor blocker, as it may be linked to a cancer risk. This follows several other suppliers of Zantac in the US such as Walgreens, Walmart and Rite Aid. The active ingredient in Zantac is ranitidine but it is the presence of NDMA in ranitidine-containing products which is the cause of concern.</p><hr class="hidden"><p style="text-align: center;"><img alt="" class="noborder" src="../../../ib/chemistry/images/2014-blog/ndma.png" style="width: 451px; height: 204px;"></p><p style="text-align: center;">The structure of N-nitrosodimethylamine (NDMA)</p><hr class="hidden"><p>NDMA is N-nitrosodimethylamine and although found in very small quantities of some foodstuffs, such as meat and dairy products, it is a known carcinogen. Many countries around the world are now suspending the sale of any ranitidine-containing products (and in some cases actually recalling products already sold) until the dangers of the NDMA content have been properly evaluated.</p></div>
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Please enable cookies to log in.</div><div class="alert alert-info"><i class="fa fa-question-circle"></i> Enabling cookies in <a target="_blank" style="margin: 0; padding: 0;" href="https://support.mozilla.org/en-US/kb/enable-and-disable-cookies-website-preferences">Firefox</a>, <a target="_blank" style="margin: 0; padding: 0;" href="https://support.google.com/accounts/answer/61416?hl=en">Chrome</a>, <a target="_blank" style="margin: 0; padding: 0;" href="http://windows.microsoft.com/en-us/windows-vista/block-or-allow-cookies">Explorer</a></div>';$("#modal-login .modal-header").append(msg)}if($(".panel-expandable > .panel-heading").click((function(e){e.preventDefault();var panel=$(this).closest(".panel-expandable"),expandables=panel.hasClass("panel-has-footer")?".panel-body, .panel-footer":".panel-body";panel.find(".panel-body").is(":visible")?(panel.find(expandables).slideUp("fast"),panel.find(".expander > .fa-minus").removeClass("fa-minus").addClass("fa-plus")):(panel.find(expandables).slideDown("fast"),panel.find(".expander > .fa-plus").removeClass("fa-plus").addClass("fa-minus"))})),$("#modal-find-out-more").css({width:.8*$("#container").width()+"px","margin-left":-.4*$("#container").width()+"px"}),$(".modal-xxl").length){var modalTopPos=Math.round(.07*$(window).height());$(window).width()>1200&&$(".modal-xxl").css({"max-width":$(window).width()>960?"960px":$(window).width()+"px",width:$(window).width()>960?"960px":$(window).width()+"px","margin-left":$(window).width()>960?"-480px":Math.round($(window).width()/2)}),$(".modal-xxl").css("top",modalTopPos+"px"),$(".modal-xxl").on("shown",(function(){var mHeaderH=$(this).find(".modal-header").outerHeight(),mBody=$(this).find(".modal-body"),mBodyH=mBody.outerHeight(),mFooterH=$(this).find(".modal-footer").outerHeight(),bottomOfTheModal=modalTopPos+mHeaderH+mBodyH+mFooterH;if(bottomOfTheModal<$(window).height())mBodyH+=$(window).height()-bottomOfTheModal-60,mBody.css("max-height",mBodyH+"px");else{$(window).scrollTop(0),modalTopPos=10,$(".modal-xxl").css("top",modalTopPos+"px"),bottomOfTheModal=modalTopPos+mHeaderH+mBodyH+mFooterH,availableScroll=bottomOfTheModal-$(window).height()+modalTopPos;var lastPos=-1;$(window).on("scroll",(function(){var s=$(window).scrollTop()>availableScroll?availableScroll:$(window).scrollTop();newPos=modalTopPos-s,newPos!=lastPos&&($(".modal-xxl").css("top",newPos+"px"),lastPos=newPos)}))}}))}function popupHelp(url,title,w,h){var dualScreenLeft=void 0!==window.screenLeft?window.screenLeft:screen.left,dualScreenTop=void 0!==window.screenTop?window.screenTop:screen.top,width,height,left=(window.innerWidth?window.innerWidth:document.documentElement.clientWidth?document.documentElement.clientWidth:screen.width)/2-w/2+dualScreenLeft,top=(window.innerHeight?window.innerHeight:document.documentElement.clientHeight?document.documentElement.clientHeight:screen.height)/2-h/2+dualScreenTop,newWindow=window.open(url,title,"menubar=no,location=no,resizable=0, width="+w+", height="+h+", top="+top+", left="+left);return window.focus&&(newWindow?newWindow.focus():$('<div class="alert alert-warning" style="margin-bottom: 0px;"><p class="help-block">Pop Up blocked. Please allow Pop Ups in your browser settings.</p></div>').insertBefore("body")),newWindow}if($(".open-student-access-help").click((function(e){e.preventDefault();var h=$(window).height()-20,w=$(window).width()<1280?$(window).width():1280;popupHelp(helpURL,"Student Access Help",w,h)})),$(".pop-up-help").click((function(e){e.preventDefault();var url=$(this).attr("href"),title=$(this).data("title"),h=$(window).height()-20,w;popupHelp(url,title,$(window).width()<1280?$(window).width():1280,h)})),$("section.tib-hiddenbox").length){var count=0;$($("section.tib-hiddenbox").get().reverse()).each((function(){var box=$(this),revealButton;$("<a />").attr("class","btn showhider").attr("rel","hiddenBoxContent"+count).attr("style","margin-bottom: 0;").html('<i class="fa fa-eye"></i>').insertBefore(box);var newContainer=$("<div />").attr("class","hidden-content").attr("id","hiddenBoxContent"+count).html(box.html());newContainer.hide(),newContainer.insertBefore(box),box.remove(),count++})),$("a.showhider").on("click",(function(e){var container=$("#"+$(this).attr("rel"));container.is(":hidden")?(container.fadeIn("fast"),$(this).html('<i class="fa fa-eye-slash"></i>')):(container.fadeOut("fast"),$(this).html('<i class="fa fa-eye"></i>'))}))}
			let commentEditor={};function initCommentsEditor(){const t=document.querySelector("#comment-content");t&&CKEDITOR.BasicEditor.create(t,{toolbar:{viewportTopOffset:50,items:["bold","italic","link","subscript","superscript"]},link:{decorators:{addLinkNoFollow:{mode:"automatic",callback:function(t){if(null!=t)return["http://","http://www","https://","https://www","ftp:"].some((o=>t.startsWith(o)))},attributes:{target:"_blank",class:"ck-link",rel:"nofollow"}}}}}).then((function(t){commentEditor=t,commentEditor.execute("heading",{value:"paragraph"})})).catch((function(t){console.error(t)}))}function replaceComment(content,commentId){$("#cancel-comment-post").trigger("click"),$("#comm-"+commentId+" > .comment-content div.comment-text").html(content)}function placeComment(html,fatherId){$("#comment-form").hide(),$("#comment-form textarea").val(""),fatherId>0?($("#comments #comm-"+fatherId).append(html),$("#comments").append($("#comment-form"))):$("#comments").append(html).append($("#comment-form")),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content").removeClass("marked"),$("#comment-form").show("fast")}function update_sticky_comments(arrIds,mode){$.post("pages/edit/update-sticky-comments.php?mode="+mode,{ids:arrIds,ticket:$("#comment-ticket").val()},(function(data){1==data.success?("set"==data.mode&&$("#sticky-"+data.id).parents("div.comment").each((function(e){$(this).find("a.pull-right").first().addClass("sticky"),$(this).find("a.pull-right").first().attr("title","Unmark as important")})),"unset"==data.mode&&($("#sticky-"+data.id).removeClass("sticky"),$("#sticky-"+data.id).attr("title","Mark as important"),$("#sticky-"+data.id).closest("div.comment").find("div.comment").each((function(e){$(this).find("a.pull-right").first().removeClass("sticky"),$(this).find("a.pull-right").first().attr("title","Mark as important")})))):alert(data.error)}),"json")}"undefined"!=typeof CKEDITOR&&initCommentsEditor(),$("section#comments").on("click","#edit-comment",(function(e){e.preventDefault();var commentId=$("form#comment-form #comment-mode").val(),commentContent=commentEditor.getData(),ticket=$("#comment-ticket").val(),sectionId=$("#section-id").val();$.post("pages/comment.php",{action:"edit",comment_id:commentId,content:commentContent,ticket:ticket},(function(data){"0"==data.success?alert(data.error):replaceComment(data.text,commentId)}),"json")})),$("section#comments").on("click","a.edit-comment",(function(e){e.preventDefault(),$(".comment .hidden").removeClass("hidden");var commentId=$(this).data("comment-id"),form=$("form#comment-form"),text=$("#comm-"+commentId+" > .comment-content div.comment-text").html();commentEditor.setData(text),$("form#comment-form textarea").val(""),$("form#comment-form textarea").val(text),$("#comm-"+commentId+" > .comment-content > img").addClass("hidden"),$("#comm-"+commentId+" > .comment-content > div.comment-text").addClass("hidden"),$("#comm-"+commentId+" > .comment-footer").addClass("hidden"),$("#comm-"+commentId+" > .comment-content").append(form),$("form#comment-form #submit-comment").hide(),$("form#comment-form #edit-comment").show(),$("form#comment-form #cancel-comment-post").show(),$("form#comment-form #comment-mode").val(commentId),fancyScrollTo("comment-form"),$("form#comment-form textarea").focus()})),$("section#comments").on("click","#submit-comment",(function(e){e.preventDefault();var commentContent=commentEditor.getData(),fatherId=$("#father-comment").val(),ticket=$("#comment-ticket").val(),sectionId=$("#section-id").val();$.post("pages/comment.php",{action:"post",section_id:sectionId,father_id:fatherId,content:commentContent,ticket:ticket},(function(data){if("0"==data.success)alert(data.error);else{commentEditor.setData(""),placeComment(data.html,fatherId),$("form#comment-form #cancel-comment-post").hide();var n=0;$("#n-comments").text().length>0&&(n=parseInt($("#n-comments").text())),$("#n-comments").text(n+1)}}),"json")})),$("section#comments").on("click","a.reply-comment",(function(e){e.preventDefault(),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content").removeClass("marked");var form=$("form#comment-form"),fatherId=$(this).parent().parent(".comment").attr("rel");form.find("#father-comment").val(fatherId),$(this).parent().parent(".comment").find("> .reply-area").append(form),$(this).find(".fa-reply").removeClass("fa-reply").addClass("fa-arrow-down"),$(this).parent().prev(".comment-content").addClass("marked"),$("form#comment-form #cancel-comment-post").show(),fancyScrollTo("comment-form"),$("form#comment-form textarea").focus()})),$("section#comments").on("click","#cancel-comment-post",(function(e){e.preventDefault(),$(".comment .hidden").removeClass("hidden"),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content.marked").removeClass("marked"),commentEditor.setData("");var form=$("form#comment-form");$("section#comments").append(form),$("form#comment-form #father-comment").val("0"),$("form#comment-form textarea").val(""),$("form#comment-form #comment-mode").val("new"),$("#edit-comment").hide(),$(this).hide(),$("#submit-comment").show()})),$("section#comments").on("click","a.delete-comment",(function(e){var commentId=$(this).data("comment-id"),isFather=$("#comm-"+commentId).children(".comment").length>0,ticket=$("#comment-ticket").val(),msg="You are going to delete a comment.\n\nThis action cannot be undone.\n\nAre you sure?";isFather&&(msg="You are going to delete a comment and all its replies.\n\nThis action cannot be undone.\n\nAre you sure?"),confirm(msg)&&$.post("pages/comment.php",{action:"delete",comment_id:commentId,is_father:isFather,ticket:ticket},(function(data){if("0"==data.success)alert(data.error);else{$("#comm-"+commentId+".comment").replaceWith(data.text);var n=0;$("#n-comments").text().length&&(n=parseInt($("#n-comments").text())),$("#n-comments").text(n-parseInt(data.deleted))}}),"json"),e.preventDefault(),e.stopPropagation()})),$("section#comments").on("click","a.pull-right",(function(e){e.preventDefault();var arrayIds=[];$(this).hasClass("sticky")?(arrayIds.push($(this).closest("div.comment").attr("rel")),$(this).closest("div.comment").find("div.comment").each((function(e){arrayIds.push($(this).attr("rel"))})),update_sticky_comments(arrayIds,"unset")):($(this).parents("div.comment").each((function(e){arrayIds.push($(this).attr("rel"))})),update_sticky_comments(arrayIds,"set"))}));
$('.page-bookmarker').click(function(e){
	e.preventDefault();
	var pid = $(this).data('pid');
	var random = $(this).data('ticket');
	bookmarkPage(pid, random);
});

function bookmarkPage(pageId, random){
	$.get(
		'pages/bookmarks.php',
		{
			'id'		: pageId,
			'ticket'	: random
		},
		function(data){
			if(data['success'] == '1') {
				var buttonTitle = 'Favourite';
				if( $('.page-bookmarker').attr('title') == 'Favourite' ) {
					buttonTitle = 'Unfavourite';
				}
				
				$('.page-bookmarker > i').toggleClass('colored');

				$('.page-bookmarker.stacked > span').text(buttonTitle);
				$('.page-bookmarker').attr('title', buttonTitle);
			}
		},
		'json'
	);
}

// the comment icon becomes a popover
$('img.ico[src="/img/icons/comments.png"]').each(function(){
	var comment = $(this).attr('title');
	$(this).removeAttr('title');
	$(this).wrap('<a class="tib-popover" href="#" data-content="'+comment+'" data-togle="popover" data-placement="top" />');
});
$('img.ico[src="img/icons/comments.png"]').each(function(){
	var comment = $(this).attr('title');
	$(this).removeAttr('title');
	$(this).wrap('<a class="tib-popover" href="#" data-content="'+comment+'" data-togle="popover" data-placement="top" />');
});

$('.tib-popover').popover({
	html 		: true,
	trigger		: 'hover',
	delay		: {show: 300, hide: 300},
	placement	: function (context, source) {
		var position = $(source).position();
		if (position.top > 200)	 {  return "top";}
		if (position.left < 515) {	return "right"; }
		if (position.top < 200)	 {  return "bottom";}
		if (position.left > 515) {	return "left";	}
									return "top";
	}
}).click(function(e){
	e.preventDefault();
});

// LIVE CAROUSEL MANAGEMENT

// Miliseconds for the next slide
var carouselTime = 6500;

// Start carousels
$('div.carousel.slide').carousel({interval: carouselTime});

$('.tib-indicators > img').click(function(){
	// IN
	var index = $(this).index();
	var container = $(this).closest('.carousel.slide');
	container.carousel(index);
});
$('a.btn.showhider').click(function(e) {
    var showHiderId = $( this ).attr('rel');
    if ( $('#'+showHiderId).find('iframe').length > 0 ) {
        $('#'+showHiderId+' iframe').each(function() {
            if ( $(this).attr('src').indexOf('.pdf') > 0 ) {
                this.contentWindow.location.reload(true);
            }
        });
    }
});

var hTopmenu = $('#topmenu').height();
var n = 0;
$('nav.top-nav > ul > li').each(function(k, e) {
    if (n > 1) {
        var diff = hTopmenu-(e.offsetTop+e.offsetHeight);
        $(e).find(' > ul ').css('margin-top', '-'+diff+'px');
    }
    n++;
});

		});
	</script>
</body>
</html>