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  <meta name="description" content="One of the reasons why life expectancy is starting to fall in certain parts of the world is the increase in obesity.The number of overweight and obese people worldwide has increased from 857 million in 1980 to 2.1 billion in 2013. Of these, 671 million are obese. (Source: Medical News Today)Recent studies by a team led...">
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href="../../page/23929/genuine-examples-of-moderated-ia-reports.html">Genuine examples of moderated IA reports</a></li><li><a href="../../page/25234/examples-of-teacher-marked-ia-reports-.html">Examples of teacher-marked IA reports </a></li><li><a href="../../page/37542/history-of-internal-assessment.html">History of Internal Assessment</a></li></ul></li><li><a href="../../page/16598/mandatory-laboratory-components.html" class="father">Mandatory laboratory components</a><ul class="level-2"><li><a href="../../page/16613/formula-of-magnesium-oxide-.html">Formula of magnesium oxide </a></li><li><a href="../../page/16612/determining-the-mr-of-an-unknown-gas.html">Determining the <i>M</i><sub>r</sub> of an unknown gas</a></li><li><a href="../../page/16615/acid-base-titrations-.html">Acid-base titrations </a></li><li><a href="../../page/16616/a-green-acid-base-practical.html">A green acid-base practical</a></li><li><a href="../../page/16617/analysis-of-aspirin-tablets.html">Analysis of 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href="../../page/18351/chlorine-in-swimming-pools-.html">Chlorine in swimming pools </a></li><li><a href="../../page/18178/analysis-of-cuii-ions-in-solution-.html">Analysis of Cu(II) ions in solution </a></li><li><a href="../../page/18179/percentage-of-copper-in-brass.html">Percentage of copper in brass</a></li><li><a href="../../page/18356/electrolytic-cells-.html">Electrolytic cells </a></li><li><a href="../../page/18598/reactions-of-organic-compounds.html">Reactions of organic compounds</a></li><li><a href="../../page/18752/hydrolysis-of-halogenoalkanes.html">Hydrolysis of halogenoalkanes</a></li><li><a href="../../page/18784/preparation-of-13-dinitrobenzene-.html">Preparation of 1,3-dinitrobenzene </a></li><li><a href="../../page/19022/determination-of-an-organic-structure.html">Determination of an organic structure</a></li><li><a href="../../page/19887/preparation-of-nylon-66.html">Preparation of nylon 6,6</a></li><li><a href="../../page/19343/determination-of-vitamin-c-content-.html">Determination of vitamin C content </a></li><li><a href="../../page/19342/hydrolysis-of-starch-.html">Hydrolysis of starch </a></li><li><a href="../../page/19159/preparation-purification-of-aspirin-.html">Preparation & purification of aspirin </a></li></ul></li><li><a href="../../page/18851/ict-in-practical-work.html" class="father">ICT in practical work</a><ul class="level-2"><li><a href="../../page/18852/data-logging-.html">Data logging </a></li><li><a href="../../page/18853/software-for-graph-plotting-.html">Software for graph plotting </a></li><li><a href="../../page/18854/spreadsheets-for-data-processing-.html">Spreadsheets for data processing </a></li><li><a href="../../page/18855/databases.html">Databases</a></li><li><a href="../../page/18856/computer-modelling-simulations-.html">Computer modelling & simulations </a></li></ul></li><li><a href="../../page/16594/group-4-project.html" class="father">Group 4 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            <h1 class="section-title">Applying IB chemistry to a diet pill</h1>
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                Sunday 23 September 2018
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                <div style="padding: 0 30px;"><p>One of the reasons why life expectancy is starting to fall in certain parts of the world is the increase in obesity.</p><hr class="hidden"><p style="text-align: center;"><img alt="" class="noborder" src="../../../ib/chemistry/images/blog/obesity-1.png" style="width: 589px; height: 248px;" title="Image from http://foothillsfamilycarellc.com/psfh/diseases/obesity/"></p><p>The number of overweight and obese people worldwide has increased from 857 million in 1980 to 2.1 billion in 2013. Of these, 671 million are obese. (Source: <a href="https://www.medicalnewstoday.com/articles/277450.php">Medical News Today</a>)</p><hr class="hidden"><p>Recent studies by a team led by Dr Erin Bohula <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1808721">published in the New England Journal of Medicine</a> have identified a drug which can reduce weight in humans. The study, which involved 12,000 people who were either obese or overweight, showed that those who took the drug lorcaserin twice a day lost an average of 4 kg (approximately 9 lbs) in 40 months compared to those who took a placebo. This is not a huge weight loss and dieticians still stress the necessity for a healthy diet coupled with regular exercise. The importance of the study though is that, unlike other appetite suppressers, lorcaserin, appears to have no serious long-term adverse effects on the heart. It is thought to work by suppressing appetite by activating a type of seratonin receptor known as 5-HT2C in the hypothalamus.</p><hr class="hidden"><p style="text-align: center;"></p><p style="text-align: center;"><img alt="" class="noborder" src="../../../ib/chemistry/images/2014-blog/lorcaserin1-296x178.png" style="width: 296px; height: 178px;"></p><p style="text-align: center;">lorcaserin</p><hr class="hidden"><p>Lorcaserin has an interesting structure and could be used in your teaching to check whether students can apply what they have learned during the course (Topics 10, 11, 18, 20 and Option D) to a real life example.</p><hr class="hidden"><p><strong>1.&nbsp;</strong>Deduce the molecular formular of lorcaserin.</p><section class="tib-hiddenbox"><div><p>C<sub>11</sub>H<sub>14</sub>ClN&nbsp; <span style="color:#FF0000;">(Topic 10.1: Skeletal formulas should be discussed in the course.)</span></p></div></section><hr class="hidden"><p><strong>2.</strong> Calculate the index of hydrogen deficiency (IHD) of lorcaserin.</p><section class="tib-hiddenbox"><div><p>C<sub>11</sub>H<sub>14</sub>ClN&nbsp; is equivalent to C<sub>12</sub>H<sub>16</sub> so IHD = 5 <span style="color:#FF0000;">(Topic 11.3)</span></p></div></section><hr class="hidden"><p><strong>3.</strong> Predict whether or not lorcaserin will readily undergo an electrophilic addition reaction with bromine.</p><section class="tib-hiddenbox"><div><p>The extra stability due to the delocalization of electrons in the phenyl functional group means that it will <strong>not </strong>readily undergo electrophilic addition reactions. <span style="color:#FF0000;">(Topic 10.2)</span></p></div></section><hr class="hidden"><p><strong>4.</strong> Deduce whether lorcaserin is a weak acid, a weak base or a neutral substance.</p><section class="tib-hiddenbox"><div><p>It will be a weak base as the non-bonding pair of electrons on the N atom can attract a proton. <span style="color:#FF0000;">(Topic 18.1)</span></p></div></section><hr class="hidden"><p><strong>5.</strong> Suggest why lorcaserin is normally administered as a salt, such as lorcaserin hydrochloride.</p><section class="tib-hiddenbox"><div><p>It will make it more soluble in aqueous solution. Once in the strongly acidic environment of the stomach it will revert back to the unionized form. <span style="color:#FF0000;">(Topic D.2)</span></p></div></section><hr class="hidden"><p><strong>6. </strong>Explain whether structure B represents an enantiomer of lorcaserin as shown in structure A.</p><p style="text-align: center;">&nbsp;<img alt="" class="noborder" src="../../../ib/chemistry/images/2014-blog/lorcaserin-a---b.png" style="width: 477px; height: 188px;"></p><section class="tib-hiddenbox"><div><p>They are both representation of the same enantiomer as structure B is simply structure A rotated by 180<sup>o</sup>.</p><p>The correct structure for the enantiomer is <img alt="" class="noborder" src="../../../ib/chemistry/images/2014-blog/lorcaserin-enantiomer-296x178.png" style="width: 148px; height: 89px;"></p></div></section></div>
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fancyParent=1==$("body").find($("#main-article")).length?"#main-article":"body",fancyOptions={loop:!1,openEffect:"elastic",closeEffect:"elastic",nextEffect:"fade",prevEffect:"fade",parent:fancyParent,helpers:{title:{type:"inside"}}};if($("ul.gallery").each((function(){var rel=$(this).find("li:first-child > a:first-child").attr("rel");$('ul.gallery a.fancy[rel="'+rel+'"]').fancybox(fancyOptions)})),$(".carousel.slide").each((function(){var rel="gallery-"+$(this).data("id");$('.carousel.slide a.fancy[rel="'+rel+'"]').fancybox(fancyOptions)})),$("img.pop").parent("a").each((function(){$(this).attr("title",$(this).children("img").attr("alt"))})),$("img.pop").parent("a").fancybox({loop:!1,helpers:{title:{type:"inside"}}}),!are_cookies_enabled()){var msg='<div class="alert alert-error"><i class="fa fa-warning"></i> Your browser does not accept cookies from this site. Please enable cookies to log in.</div><div class="alert alert-info"><i class="fa fa-question-circle"></i> Enabling cookies in <a target="_blank" style="margin: 0; padding: 0;" href="https://support.mozilla.org/en-US/kb/enable-and-disable-cookies-website-preferences">Firefox</a>, <a target="_blank" style="margin: 0; padding: 0;" href="https://support.google.com/accounts/answer/61416?hl=en">Chrome</a>, <a target="_blank" style="margin: 0; padding: 0;" href="http://windows.microsoft.com/en-us/windows-vista/block-or-allow-cookies">Explorer</a></div>';$("#modal-login .modal-header").append(msg)}if($(".panel-expandable > .panel-heading").click((function(e){e.preventDefault();var panel=$(this).closest(".panel-expandable"),expandables=panel.hasClass("panel-has-footer")?".panel-body, .panel-footer":".panel-body";panel.find(".panel-body").is(":visible")?(panel.find(expandables).slideUp("fast"),panel.find(".expander > .fa-minus").removeClass("fa-minus").addClass("fa-plus")):(panel.find(expandables).slideDown("fast"),panel.find(".expander > .fa-plus").removeClass("fa-plus").addClass("fa-minus"))})),$("#modal-find-out-more").css({width:.8*$("#container").width()+"px","margin-left":-.4*$("#container").width()+"px"}),$(".modal-xxl").length){var modalTopPos=Math.round(.07*$(window).height());$(window).width()>1200&&$(".modal-xxl").css({"max-width":$(window).width()>960?"960px":$(window).width()+"px",width:$(window).width()>960?"960px":$(window).width()+"px","margin-left":$(window).width()>960?"-480px":Math.round($(window).width()/2)}),$(".modal-xxl").css("top",modalTopPos+"px"),$(".modal-xxl").on("shown",(function(){var mHeaderH=$(this).find(".modal-header").outerHeight(),mBody=$(this).find(".modal-body"),mBodyH=mBody.outerHeight(),mFooterH=$(this).find(".modal-footer").outerHeight(),bottomOfTheModal=modalTopPos+mHeaderH+mBodyH+mFooterH;if(bottomOfTheModal<$(window).height())mBodyH+=$(window).height()-bottomOfTheModal-60,mBody.css("max-height",mBodyH+"px");else{$(window).scrollTop(0),modalTopPos=10,$(".modal-xxl").css("top",modalTopPos+"px"),bottomOfTheModal=modalTopPos+mHeaderH+mBodyH+mFooterH,availableScroll=bottomOfTheModal-$(window).height()+modalTopPos;var lastPos=-1;$(window).on("scroll",(function(){var s=$(window).scrollTop()>availableScroll?availableScroll:$(window).scrollTop();newPos=modalTopPos-s,newPos!=lastPos&&($(".modal-xxl").css("top",newPos+"px"),lastPos=newPos)}))}}))}function popupHelp(url,title,w,h){var dualScreenLeft=void 0!==window.screenLeft?window.screenLeft:screen.left,dualScreenTop=void 0!==window.screenTop?window.screenTop:screen.top,width,height,left=(window.innerWidth?window.innerWidth:document.documentElement.clientWidth?document.documentElement.clientWidth:screen.width)/2-w/2+dualScreenLeft,top=(window.innerHeight?window.innerHeight:document.documentElement.clientHeight?document.documentElement.clientHeight:screen.height)/2-h/2+dualScreenTop,newWindow=window.open(url,title,"menubar=no,location=no,resizable=0, width="+w+", height="+h+", top="+top+", left="+left);return window.focus&&(newWindow?newWindow.focus():$('<div class="alert alert-warning" style="margin-bottom: 0px;"><p class="help-block">Pop Up blocked. Please allow Pop Ups in your browser settings.</p></div>').insertBefore("body")),newWindow}if($(".open-student-access-help").click((function(e){e.preventDefault();var h=$(window).height()-20,w=$(window).width()<1280?$(window).width():1280;popupHelp(helpURL,"Student Access Help",w,h)})),$(".pop-up-help").click((function(e){e.preventDefault();var url=$(this).attr("href"),title=$(this).data("title"),h=$(window).height()-20,w;popupHelp(url,title,$(window).width()<1280?$(window).width():1280,h)})),$("section.tib-hiddenbox").length){var count=0;$($("section.tib-hiddenbox").get().reverse()).each((function(){var box=$(this),revealButton;$("<a />").attr("class","btn showhider").attr("rel","hiddenBoxContent"+count).attr("style","margin-bottom: 0;").html('<i class="fa fa-eye"></i>').insertBefore(box);var newContainer=$("<div />").attr("class","hidden-content").attr("id","hiddenBoxContent"+count).html(box.html());newContainer.hide(),newContainer.insertBefore(box),box.remove(),count++})),$("a.showhider").on("click",(function(e){var container=$("#"+$(this).attr("rel"));container.is(":hidden")?(container.fadeIn("fast"),$(this).html('<i class="fa fa-eye-slash"></i>')):(container.fadeOut("fast"),$(this).html('<i class="fa fa-eye"></i>'))}))}
			let commentEditor={};function initCommentsEditor(){const t=document.querySelector("#comment-content");t&&CKEDITOR.BasicEditor.create(t,{toolbar:{viewportTopOffset:50,items:["bold","italic","link","subscript","superscript"]},link:{decorators:{addLinkNoFollow:{mode:"automatic",callback:function(t){if(null!=t)return["http://","http://www","https://","https://www","ftp:"].some((o=>t.startsWith(o)))},attributes:{target:"_blank",class:"ck-link",rel:"nofollow"}}}}}).then((function(t){commentEditor=t,commentEditor.execute("heading",{value:"paragraph"})})).catch((function(t){console.error(t)}))}function replaceComment(content,commentId){$("#cancel-comment-post").trigger("click"),$("#comm-"+commentId+" > .comment-content div.comment-text").html(content)}function placeComment(html,fatherId){$("#comment-form").hide(),$("#comment-form textarea").val(""),fatherId>0?($("#comments #comm-"+fatherId).append(html),$("#comments").append($("#comment-form"))):$("#comments").append(html).append($("#comment-form")),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content").removeClass("marked"),$("#comment-form").show("fast")}function update_sticky_comments(arrIds,mode){$.post("pages/edit/update-sticky-comments.php?mode="+mode,{ids:arrIds,ticket:$("#comment-ticket").val()},(function(data){1==data.success?("set"==data.mode&&$("#sticky-"+data.id).parents("div.comment").each((function(e){$(this).find("a.pull-right").first().addClass("sticky"),$(this).find("a.pull-right").first().attr("title","Unmark as important")})),"unset"==data.mode&&($("#sticky-"+data.id).removeClass("sticky"),$("#sticky-"+data.id).attr("title","Mark as important"),$("#sticky-"+data.id).closest("div.comment").find("div.comment").each((function(e){$(this).find("a.pull-right").first().removeClass("sticky"),$(this).find("a.pull-right").first().attr("title","Mark as important")})))):alert(data.error)}),"json")}"undefined"!=typeof CKEDITOR&&initCommentsEditor(),$("section#comments").on("click","#edit-comment",(function(e){e.preventDefault();var commentId=$("form#comment-form #comment-mode").val(),commentContent=commentEditor.getData(),ticket=$("#comment-ticket").val(),sectionId=$("#section-id").val();$.post("pages/comment.php",{action:"edit",comment_id:commentId,content:commentContent,ticket:ticket},(function(data){"0"==data.success?alert(data.error):replaceComment(data.text,commentId)}),"json")})),$("section#comments").on("click","a.edit-comment",(function(e){e.preventDefault(),$(".comment .hidden").removeClass("hidden");var commentId=$(this).data("comment-id"),form=$("form#comment-form"),text=$("#comm-"+commentId+" > .comment-content div.comment-text").html();commentEditor.setData(text),$("form#comment-form textarea").val(""),$("form#comment-form textarea").val(text),$("#comm-"+commentId+" > .comment-content > img").addClass("hidden"),$("#comm-"+commentId+" > .comment-content > div.comment-text").addClass("hidden"),$("#comm-"+commentId+" > .comment-footer").addClass("hidden"),$("#comm-"+commentId+" > .comment-content").append(form),$("form#comment-form #submit-comment").hide(),$("form#comment-form #edit-comment").show(),$("form#comment-form #cancel-comment-post").show(),$("form#comment-form #comment-mode").val(commentId),fancyScrollTo("comment-form"),$("form#comment-form textarea").focus()})),$("section#comments").on("click","#submit-comment",(function(e){e.preventDefault();var commentContent=commentEditor.getData(),fatherId=$("#father-comment").val(),ticket=$("#comment-ticket").val(),sectionId=$("#section-id").val();$.post("pages/comment.php",{action:"post",section_id:sectionId,father_id:fatherId,content:commentContent,ticket:ticket},(function(data){if("0"==data.success)alert(data.error);else{commentEditor.setData(""),placeComment(data.html,fatherId),$("form#comment-form #cancel-comment-post").hide();var n=0;$("#n-comments").text().length>0&&(n=parseInt($("#n-comments").text())),$("#n-comments").text(n+1)}}),"json")})),$("section#comments").on("click","a.reply-comment",(function(e){e.preventDefault(),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content").removeClass("marked");var form=$("form#comment-form"),fatherId=$(this).parent().parent(".comment").attr("rel");form.find("#father-comment").val(fatherId),$(this).parent().parent(".comment").find("> .reply-area").append(form),$(this).find(".fa-reply").removeClass("fa-reply").addClass("fa-arrow-down"),$(this).parent().prev(".comment-content").addClass("marked"),$("form#comment-form #cancel-comment-post").show(),fancyScrollTo("comment-form"),$("form#comment-form textarea").focus()})),$("section#comments").on("click","#cancel-comment-post",(function(e){e.preventDefault(),$(".comment .hidden").removeClass("hidden"),$(".comment .fa-arrow-down").removeClass("fa-arrow-down").addClass("fa-reply"),$(".comment-content.marked").removeClass("marked"),commentEditor.setData("");var form=$("form#comment-form");$("section#comments").append(form),$("form#comment-form #father-comment").val("0"),$("form#comment-form textarea").val(""),$("form#comment-form #comment-mode").val("new"),$("#edit-comment").hide(),$(this).hide(),$("#submit-comment").show()})),$("section#comments").on("click","a.delete-comment",(function(e){var commentId=$(this).data("comment-id"),isFather=$("#comm-"+commentId).children(".comment").length>0,ticket=$("#comment-ticket").val(),msg="You are going to delete a comment.\n\nThis action cannot be undone.\n\nAre you sure?";isFather&&(msg="You are going to delete a comment and all its replies.\n\nThis action cannot be undone.\n\nAre you sure?"),confirm(msg)&&$.post("pages/comment.php",{action:"delete",comment_id:commentId,is_father:isFather,ticket:ticket},(function(data){if("0"==data.success)alert(data.error);else{$("#comm-"+commentId+".comment").replaceWith(data.text);var n=0;$("#n-comments").text().length&&(n=parseInt($("#n-comments").text())),$("#n-comments").text(n-parseInt(data.deleted))}}),"json"),e.preventDefault(),e.stopPropagation()})),$("section#comments").on("click","a.pull-right",(function(e){e.preventDefault();var arrayIds=[];$(this).hasClass("sticky")?(arrayIds.push($(this).closest("div.comment").attr("rel")),$(this).closest("div.comment").find("div.comment").each((function(e){arrayIds.push($(this).attr("rel"))})),update_sticky_comments(arrayIds,"unset")):($(this).parents("div.comment").each((function(e){arrayIds.push($(this).attr("rel"))})),update_sticky_comments(arrayIds,"set"))}));
$('.page-bookmarker').click(function(e){
	e.preventDefault();
	var pid = $(this).data('pid');
	var random = $(this).data('ticket');
	bookmarkPage(pid, random);
});

function bookmarkPage(pageId, random){
	$.get(
		'pages/bookmarks.php',
		{
			'id'		: pageId,
			'ticket'	: random
		},
		function(data){
			if(data['success'] == '1') {
				var buttonTitle = 'Favourite';
				if( $('.page-bookmarker').attr('title') == 'Favourite' ) {
					buttonTitle = 'Unfavourite';
				}
				
				$('.page-bookmarker > i').toggleClass('colored');

				$('.page-bookmarker.stacked > span').text(buttonTitle);
				$('.page-bookmarker').attr('title', buttonTitle);
			}
		},
		'json'
	);
}

// the comment icon becomes a popover
$('img.ico[src="/img/icons/comments.png"]').each(function(){
	var comment = $(this).attr('title');
	$(this).removeAttr('title');
	$(this).wrap('<a class="tib-popover" href="#" data-content="'+comment+'" data-togle="popover" data-placement="top" />');
});
$('img.ico[src="img/icons/comments.png"]').each(function(){
	var comment = $(this).attr('title');
	$(this).removeAttr('title');
	$(this).wrap('<a class="tib-popover" href="#" data-content="'+comment+'" data-togle="popover" data-placement="top" />');
});

$('.tib-popover').popover({
	html 		: true,
	trigger		: 'hover',
	delay		: {show: 300, hide: 300},
	placement	: function (context, source) {
		var position = $(source).position();
		if (position.top > 200)	 {  return "top";}
		if (position.left < 515) {	return "right"; }
		if (position.top < 200)	 {  return "bottom";}
		if (position.left > 515) {	return "left";	}
									return "top";
	}
}).click(function(e){
	e.preventDefault();
});

// LIVE CAROUSEL MANAGEMENT

// Miliseconds for the next slide
var carouselTime = 6500;

// Start carousels
$('div.carousel.slide').carousel({interval: carouselTime});

$('.tib-indicators > img').click(function(){
	// IN
	var index = $(this).index();
	var container = $(this).closest('.carousel.slide');
	container.carousel(index);
});
$('a.btn.showhider').click(function(e) {
    var showHiderId = $( this ).attr('rel');
    if ( $('#'+showHiderId).find('iframe').length > 0 ) {
        $('#'+showHiderId+' iframe').each(function() {
            if ( $(this).attr('src').indexOf('.pdf') > 0 ) {
                this.contentWindow.location.reload(true);
            }
        });
    }
});

var hTopmenu = $('#topmenu').height();
var n = 0;
$('nav.top-nav > ul > li').each(function(k, e) {
    if (n > 1) {
        var diff = hTopmenu-(e.offsetTop+e.offsetHeight);
        $(e).find(' > ul ').css('margin-top', '-'+diff+'px');
    }
    n++;
});

		});
	</script>
</body>
</html>