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genes & alleles">Chromosomes genes & alleles</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17822/human-genome-project.html" title="Human Genome Project">Human Genome Project</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17827/base-substitution-mutation.html" title="Base substitution mutation">Base substitution mutation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17859/chromosomes.html" title="Chromosomes">Chromosomes</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17816/karyograms-and-non-disjunction.html" title="Karyograms and non-disjunction">Karyograms and non-disjunction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17814/introduction-to-meiosis.html" title="Introduction to Meiosis">Introduction to Meiosis</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17817/theoretical-genetics-1.html" title="Theoretical Genetics 1">Theoretical Genetics 1</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23787/stargardt-disease.html" title="Stargardt disease">Stargardt disease</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17818/theoretical-genetics-2.html" title="Theoretical Genetics 2">Theoretical Genetics 2</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17819/sex-linked-genes.html" title="Sex Linked Genes">Sex Linked Genes</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../17825/is-genetics-an-embarrassment-to-biology-education-.html" title="Is genetics an embarrassment to biology education? ">Is genetics an embarrassment to biology education? </a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17809/hairy-hands-genetics-of-mid-digital-hair.html" title="Hairy Hands - genetics of mid-digital hair">Hairy Hands - genetics of mid-digital hair</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17810/pedigree-chart-phenotype-ratios.html" title="Pedigree Chart & Phenotype Ratios">Pedigree Chart & Phenotype Ratios</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17820/ia-maize-genetics-experiment.html" title="IA Maize Genetics Experiment">IA Maize Genetics Experiment</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17823/genetically-modified-organisms.html" title="Genetically Modified Organisms.">Genetically Modified Organisms.</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17824/introduction-to-cloning.html" title="Introduction to Cloning.">Introduction to Cloning.</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../33736/cloning-ethics-quiz.html" title="Cloning ethics - quiz">Cloning ethics - quiz</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17811/therapeutic-cloning-debate-.html" title="Therapeutic Cloning Debate ">Therapeutic Cloning Debate </a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../16981/ecology-activities-for-learning.html" title="Ecology Activities for Learning">Ecology Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17905/ecological-terms.html" title="Ecological terms.">Ecological terms.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17906/food-webs.html" title="Food Webs">Food Webs</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17927/mesocosm-lab.html" title="Mesocosm Lab">Mesocosm Lab</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23435/ecology-mini-investigation.html" title="Ecology mini investigation">Ecology mini investigation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33629/ecology-field-trip-at-home.html" title="Ecology field trip - at home">Ecology field trip - at home</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17907/energy-flow.html" title="Energy Flow.">Energy Flow.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17912/carbon-cycle-skills.html" title="Carbon Cycle Skills">Carbon Cycle Skills</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17908/enhanced-greenhouse-effect.html" title="Enhanced Greenhouse Effect.">Enhanced Greenhouse Effect.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17909/climate-change.html" title="Climate Change.">Climate Change.</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../16985/evolution-activities-for-learning.html" title="Evolution: Activities for Learning">Evolution: Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15988/evolution-introduction.html" title="Evolution introduction">Evolution introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15990/variation-overproduction.html" title="Variation & overproduction">Variation & overproduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15989/evolution-examples.html" title="Evolution examples">Evolution examples</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19320/classification-binomial-names.html" title="Classification & binomial names">Classification & binomial names</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15991/classification-of-plants.html" title="Classification of Plants">Classification of Plants</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../19306/plant-classification-quiz.html" title="Plant classification quiz">Plant classification quiz</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15993/classification-of-animals.html" title="Classification of Animals">Classification of Animals</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23751/classification-games.html" title="Classification games">Classification games</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18912/intro-to-cladistics.html" title="Intro to cladistics">Intro to cladistics</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18910/reclassification-of-figworts-using-cladistics.html" title="Reclassification of figworts using cladistics">Reclassification of figworts using cladistics</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../18027/humans-activities-for-learning.html" title="Humans Activities for Learning">Humans Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18028/digestion-enzymes-intro-.html" title="Digestion & Enzymes Intro ">Digestion & Enzymes Intro </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18029/ia-lipase-experiment.html" title="IA Lipase Experiment">IA Lipase Experiment</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18033/structure-of-the-digestive-system.html" title="Structure of the digestive system.">Structure of the digestive system.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18030/intestine-structure-function.html" title="Intestine Structure & Function.">Intestine Structure & Function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18031/blood-and-blood-vessels.html" title="Blood and Blood Vessels">Blood and Blood Vessels</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18032/heart-dissection-diagram.html" title="Heart Dissection & Diagram">Heart Dissection & Diagram</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18026/controlling-heartbeat.html" title="Controlling Heartbeat">Controlling Heartbeat</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18590/blood-clotting-and-heart-disease.html" title="Blood clotting and heart disease.">Blood clotting and heart disease.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18117/antigens-and-antibodies-.html" title="Antigens and antibodies ">Antigens and antibodies </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18180/hiv-and-aids.html" title="HIV and AIDS">HIV and AIDS</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18116/immune-system-.html" title="Immune System ">Immune System </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18115/alveoli-gas-exchange.html" title="Alveoli & gas exchange">Alveoli & gas exchange</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19330/ventilation-lung-disease.html" title="Ventilation & lung disease">Ventilation & lung disease</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18421/nerve-impulses.html" title="Nerve impulses.">Nerve impulses.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18461/synapses.html" title="Synapses">Synapses</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../31311/chemicals-which-affect-synapses.html" title="Chemicals which affect synapses">Chemicals which affect synapses</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19886/hormones-introduction.html" title="Hormones introduction">Hormones introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19894/homeostasis-of-glucose.html" title="Homeostasis of Glucose.">Homeostasis of Glucose.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19907/harvey-and-the-search-for-ova.html" title="Harvey and the search for ova">Harvey and the search for ova</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19908/hormones-and-the-menstrual-cycle.html" title="Hormones and the menstrual cycle">Hormones and the menstrual cycle</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19927/hormones-in-ivf.html" title="Hormones in IVF">Hormones in IVF</a></li></ul></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../17178/additional-hl.html" title="Additional HL">Additional HL</a></li><ul class="level-1 "><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17917/hl-nucleic-acids-activities-for-learning.html" title="HL Nucleic Acids Activities for Learning">HL Nucleic Acids Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17918/dna-structure-extras-for-hl.html" title="DNA structure - Extras for HL">DNA structure - Extras for HL</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16141/dna-replication-for-hl-students.html" title="DNA Replication for HL Students">DNA Replication for HL Students</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17920/transcription-extras-for-hl.html" title="Transcription - extras for HL">Transcription - extras for HL</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../37259/extension-concept-hydrolysis-of-atp.html" title="Extension concept - Hydrolysis of ATP">Extension concept - Hydrolysis of ATP</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18048/translation-ribosomes.html" title="Translation & ribosomes">Translation & ribosomes</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17921/four-levels-of-protein-structure.html" title="Four levels of protein structure">Four levels of protein structure</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../18211/hl-metabolism-activities-for-learning.html" title="HL Metabolism Activities for Learning">HL Metabolism Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19840/activation-energy-and-enzyme-pathways.html" title="Activation energy and enzyme pathways">Activation energy and enzyme pathways</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19850/emergency-room-activity-enzyme-inhibition.html" title="Emergency room activity - enzyme inhibition">Emergency room activity - enzyme inhibition</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../19865/toxicology-training-course.html" title="Toxicology training course">Toxicology training course</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17923/end-product-inhibition-of-enzymes.html" title="End product inhibition of Enzymes.">End product inhibition of Enzymes.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17922/hl-respiration-introduction.html" title="HL Respiration introduction">HL Respiration introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16207/glycolysis-and-the-krebs-cycle.html" title="Glycolysis and the Krebs Cycle">Glycolysis and the Krebs Cycle</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18214/electron-transport-chain.html" title="Electron transport chain">Electron transport chain</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16209/chloroplasts-and-photosynthesis.html" title="Chloroplasts and Photosynthesis">Chloroplasts and Photosynthesis</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16210/light-dependent-reactions.html" title="Light Dependent Reactions">Light Dependent Reactions</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16211/light-independent-reactions.html" title="Light Independent Reactions">Light Independent Reactions</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17720/hl-plant-biology-activities-for-learning.html" title="HL Plant Biology - Activities for Learning">HL Plant Biology - Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17726/leaf-stomata-transpiration.html" title="Leaf stomata & transpiration">Leaf stomata & transpiration</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17721/vascular-tissues-introduction.html" title="Vascular tissues - introduction">Vascular tissues - introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17723/transport-in-xylem.html" title="Transport in xylem">Transport in xylem</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17727/experiments-on-transpiration.html" title="Experiments on Transpiration.">Experiments on Transpiration.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17724/transpiration-and-xerophytes-.html" title="Transpiration and Xerophytes ">Transpiration and Xerophytes </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17763/phloem-and-translocation.html" title="Phloem and translocation">Phloem and translocation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17722/meristems-and-growth.html" title="Meristems and Growth.">Meristems and Growth.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17804/hormonal-control-in-plants.html" title="Hormonal control in plants">Hormonal control in plants</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17725/reproduction-in-angiosperms.html" title="Reproduction in angiosperms.">Reproduction in angiosperms.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17808/seeds-flowering-phytochromes.html" title="Seeds, flowering & phytochromes">Seeds, flowering & phytochromes</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17888/hl-genetics-activities-for-learning.html" title="HL Genetics Activities for Learning">HL Genetics Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17889/meiosis.html" title="Meiosis.">Meiosis.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17890/di-hybrid-crosses.html" title="Di-Hybrid Crosses.">Di-Hybrid Crosses.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17892/polygenic-inheritance.html" title="Polygenic Inheritance.">Polygenic Inheritance.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17891/gene-linkage-1.html" title="Gene Linkage 1">Gene Linkage 1</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17894/gene-linkage-2.html" title="Gene Linkage 2">Gene Linkage 2</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17901/gene-pools.html" title="Gene pools">Gene pools</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19670/polyploidy.html" title="Polyploidy">Polyploidy</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../19559/hl-animal-physiology-activities-for-learning.html" title="HL Animal Physiology Activities for Learning">HL Animal Physiology Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19560/antibody-production.html" title="Antibody production">Antibody production</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19566/monoclonal-antibodies.html" title="Monoclonal antibodies">Monoclonal antibodies</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19565/vaccination.html" title="Vaccination">Vaccination</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19561/muscles-joints.html" title="Muscles & joints">Muscles & joints</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19564/muscle-structure-function.html" title="Muscle structure & function.">Muscle structure & function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19681/osmoregulation.html" title="Osmoregulation">Osmoregulation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19562/kidney-and-nephrons.html" title="Kidney and nephrons.">Kidney and nephrons.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18813/gamete-formation.html" title="Gamete formation">Gamete formation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16365/fertilization-blastocyst.html" title="Fertilization & blastocyst">Fertilization & blastocyst</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20080/pregnancy-and-birth.html" title="Pregnancy and birth">Pregnancy and birth</a></li></ul></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../17193/options-.html" title="Options ">Options </a></li><ul class="level-1 "><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21490/option-a-neurobiology-activities-for-learning.html" title="Option A - Neurobiology - Activities for learning">Option A - Neurobiology - Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21399/nervous-system-formation.html" title="Nervous system formation">Nervous system formation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21401/synapses-and-nervous-system-plasticity.html" title="Synapses and nervous system plasticity">Synapses and nervous system plasticity</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21519/brain-structure-and-function.html" title="Brain structure and function">Brain structure and function</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21520/the-cerebral-cortex.html" title="The Cerebral cortex">The Cerebral cortex</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21525/sensory-receptors-and-smell.html" title="Sensory receptors and smell">Sensory receptors and smell</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21526/the-eye-and-photoreceptors.html" title="The eye and photoreceptors">The eye and photoreceptors</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33371/reflexes.html" title="Reflexes">Reflexes</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33372/conditioning-and-imprinting.html" title="Conditioning and imprinting">Conditioning and imprinting</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../25280/option-b-biotechnology-and-bioinformatics.html" title="Option B - Biotechnology and bioinformatics">Option B - Biotechnology and bioinformatics</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../32571/batch-fermentation-and-continuous-culture.html" title="Batch fermentation and continuous culture">Batch fermentation and continuous culture</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../25411/cryptic-messages-bioinformatics-introduction.html" title="Cryptic messages - bioinformatics introduction">Cryptic messages - bioinformatics introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../25364/orf-activity.html" title="ORF activity">ORF activity</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../22063/option-c-ecology-activities-for-learning.html" title="Option C - Ecology Activities for learning">Option C - Ecology Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22081/describing-communities.html" title="Describing communities">Describing communities</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22083/limits-and-zones-lab.html" title="Limits and zones lab">Limits and zones lab</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22084/symbiosis-v-competitive-exclusion.html" title="Symbiosis v Competitive exclusion">Symbiosis v Competitive exclusion</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22085/modelling-energy-flow.html" title="Modelling energy flow">Modelling energy flow</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22086/predicting-ecosystems.html" title="Predicting ecosystems">Predicting ecosystems</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22089/modelling-nutrients.html" title="Modelling nutrients">Modelling nutrients</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22088/disturbance-vs-diversity.html" title="Disturbance vs Diversity">Disturbance vs Diversity</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22807/invasive-species.html" title="Invasive species">Invasive species</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22810/biomagnification.html" title="Biomagnification">Biomagnification</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22958/plastic-debris.html" title="Plastic debris">Plastic debris</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23153/indicator-species-biotic-index.html" title="Indicator species & biotic index">Indicator species & biotic index</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23154/conservation-methods.html" title="Conservation methods">Conservation methods</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22059/biodiversity-estimations.html" title="Biodiversity estimations">Biodiversity estimations</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22060/lincoln-index-activities.html" title="Lincoln Index activities">Lincoln Index activities</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../27387/population-growth-curves.html" title="Population growth curves">Population growth curves</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../27433/fisheries-and-populations.html" title="Fisheries and populations">Fisheries and populations</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18998/nitrogen-cycle-applications.html" title="Nitrogen cycle - applications">Nitrogen cycle - applications</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../28235/phosphorus-cycle.html" title="Phosphorus cycle">Phosphorus cycle</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../20088/option-d-human-physiology-activities-for-learning.html" title="Option D - Human physiology Activities for learning">Option D - Human physiology Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20215/is-it-so-bad-to-eat-only-pizza.html" title="Is it so bad to eat only pizza?">Is it so bad to eat only pizza?</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20220/appetite-and-malnutrition.html" title="Appetite and malnutrition">Appetite and malnutrition</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20284/exocrine-glands.html" title="Exocrine glands">Exocrine glands</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20300/control-of-digestive-secretions.html" title="Control of digestive secretions">Control of digestive secretions</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20259/a-miracle-cure-for-ulcers.html" title="A miracle cure for ulcers">A miracle cure for ulcers</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20664/liver-structure-function.html" title="Liver structure & function.">Liver structure & function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20665/jaundice-liver-function.html" title="Jaundice & liver function">Jaundice & liver function</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20692/cardiac-muscle-myogenic-control.html" title="Cardiac muscle & myogenic control">Cardiac muscle & myogenic control</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20707/cardiology-role-play.html" title="Cardiology Role play">Cardiology Role play</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../24113/epidemiology-framingham-heart-study.html" title="Epidemiology - Framingham heart study">Epidemiology - Framingham heart study</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20706/pituitary-gland-and-hormones.html" title="Pituitary gland and hormones">Pituitary gland and hormones</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20732/oxygen-dissociation-curves.html" title="Oxygen dissociation curves">Oxygen dissociation curves</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20708/carbon-dioxide-and-bohr-shift.html" title="Carbon dioxide and Bohr shift">Carbon dioxide and Bohr shift</a></li></ul></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../17622/the-investigation.html" title="The Investigation">The Investigation</a></li><ul class="level-1 "><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21187/individual-investigation-skills-introduction.html" title="Individual investigation - skills introduction">Individual investigation - skills introduction</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17179/practical-scheme-of-work.html" title="Practical Scheme of Work">Practical Scheme of Work</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16860/lab-protocols-for-the-biology-ib-guide.html" title="Lab protocols for the Biology IB guide">Lab protocols for the Biology IB guide</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17623/planning-for-skills-progression.html" title="Planning for skills progression">Planning for skills progression</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17624/personal-engagement.html" title="Personal Engagement">Personal Engagement</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19063/personal-engagement-personality-quiz.html" title="Personal Engagement - personality quiz">Personal Engagement - personality quiz</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34461/three-ways-to-choose-a-topic-for-the-ia.html" title="Three ways to choose a topic for the IA">Three ways to choose a topic for the IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17625/exploration.html" title="Exploration">Exploration</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23429/focusing-a-research-question.html" title="Focusing a research question">Focusing a research question</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17626/analysis.html" title="Analysis">Analysis</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../26255/ia-analysis-anova-or-t-test.html" title="IA Analysis - ANOVA or t-test?">IA Analysis - ANOVA or t-test?</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17627/evaluation.html" title="Evaluation">Evaluation</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17628/communication.html" title="Communication">Communication</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../38973/ia-ideas-during-a-pandemic-2020-21.html" title="IA ideas during a pandemic 2020-21">IA ideas during a pandemic 2020-21</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../30218/ia-avoiding-common-errors.html" title="IA - Avoiding common errors">IA - Avoiding common errors</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34356/ia-experiments-that-could-be-done-at-home.html" title="IA Experiments that could be done at home">IA Experiments that could be done at home</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34574/ia-experiment-ideas-inspired-by-youtube.html" title="IA experiment ideas inspired by Youtube">IA experiment ideas inspired by Youtube</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../15992/6-ecological-ideas-for-your-ia.html" title="6 Ecological ideas for your IA">6 Ecological ideas for your IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../20852/30-investigation-ideas-for-biology-ia.html" title="30 investigation ideas for Biology IA">30 investigation ideas for Biology IA</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../39689/investigating-strawberries-with-a-glucose-test-meter.html" title="Investigating strawberries with a glucose test meter">Investigating strawberries with a glucose test meter</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../23240/16-new-experiment-ideas-for-biology-ia.html" title="16 new experiment ideas for Biology IA">16 new experiment ideas for Biology IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../26171/12-investigation-ideas-with-a-biological-twist.html" title="12 Investigation ideas with a biological twist.">12 Investigation ideas with a biological twist.</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../26186/body-temperature-data.html" title="Body temperature data">Body temperature data</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../19329/ia-investigation-marking-sheet.html" title="IA Investigation - marking sheet">IA Investigation - marking sheet</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21859/marking-rigour-ia-assessment-criteria.html" title="Marking rigour & IA assessment criteria.">Marking rigour & IA assessment criteria.</a></li></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../18404/quizzes-tests-revision.html" title="Quizzes tests & revision">Quizzes tests & revision</a></li><ul class="level-1 "><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17665/the-exams.html" title="The Exams">The Exams</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19051/describing-trends-in-ib-graphs.html" title="Describing trends in IB graphs">Describing trends in IB graphs</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20791/paper-3-section-a-questions.html" title="Paper 3 Section A - questions">Paper 3 Section A - questions</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../26073/graphical-analysis-skills-for-life.html" title="Graphical analysis - skills for life!">Graphical analysis - skills for life!</a></li></ul></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../18403/a3-topic-revision-sheets.html" title="A3 topic revision sheets">A3 topic revision sheets</a></li><ul class="level-2 "><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18405/topic-1-cells-revision-activities.html" title="Topic 1 - Cells revision activities">Topic 1 - Cells revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22372/topic-1-cells-sl-revision-list.html" title="Topic 1 - Cells SL revision list">Topic 1 - Cells SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19003/topic-2-molecular-biology-revision-activities.html" title="Topic 2 - Molecular biology revision activities">Topic 2 - Molecular biology revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22373/topic-2-bio-molecules-sl-revision-list.html" title="Topic 2 - Bio molecules SL revision list">Topic 2 - Bio molecules SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18999/topic-3-genetics-sl-revision-activities.html" title="Topic 3 - Genetics SL revision activities">Topic 3 - Genetics SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22378/topic-3-genetics-sl-revision-list.html" title="Topic 3 - Genetics SL revision list">Topic 3 - Genetics SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19480/topic-4-ecology-sl-revision-activities.html" title="Topic 4 - Ecology SL revision activities">Topic 4 - Ecology SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22395/topic-4-ecology-revision-list.html" title="Topic 4 - Ecology revision list">Topic 4 - Ecology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19006/topic-5-evolution-sl-revision-activities.html" title="Topic 5 - Evolution SL revision activities">Topic 5 - Evolution SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22474/topic-5-evolution-revision-list.html" title="Topic 5 - Evolution revision list">Topic 5 - Evolution revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20121/topic-6-human-physiology-sl-revision-activities.html" title="Topic 6 - human physiology SL revision activities">Topic 6 - human physiology SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22396/topic-6-human-physiology-revision-list.html" title="Topic 6 - Human physiology revision list">Topic 6 - Human physiology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20196/topic-7-nucleic-acids-hl-revision-activities.html" title="Topic 7 - Nucleic acids HL revision activities">Topic 7 - Nucleic acids HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20139/topic-7-nucleic-acids-hl-revision-list.html" title="Topic 7 - Nucleic acids HL revision list">Topic 7 - Nucleic acids HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20787/topic-8-metabolism-hl-revision-activities.html" title="Topic 8 - Metabolism HL revision activities">Topic 8 - Metabolism HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20198/topic-8-metabolism-hl-revision-list.html" title="Topic 8 - Metabolism HL revision list">Topic 8 - Metabolism HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20122/topic-9-plant-biology-hl-revision-activities.html" title="Topic 9 - Plant biology HL revision activities">Topic 9 - Plant biology HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20773/topic-9-plants-hl-revision-list.html" title="Topic 9 - Plants HL - revision list">Topic 9 - Plants HL - revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20849/topic-10-genetics-hl-revision-activities.html" title="Topic 10 - Genetics HL Revision activities">Topic 10 - Genetics HL Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20128/topic-10-genetics-hl-revision-list.html" title="Topic 10 - Genetics HL revision list">Topic 10 - Genetics HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="std-disabled" href="#" title="Topic 11 - Physiology HL Revision activities">Topic 11 - Physiology HL Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20115/topic-11-animal-physiology-revision-list.html" title="Topic 11 - Animal physiology revision list">Topic 11 - Animal physiology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23821/option-a-neurobiology-revision-activities.html" title="Option A - Neurobiology - Revision activities">Option A - Neurobiology - Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23822/option-a-neurobiology-sl-revision-list.html" title="Option A - Neurobiology SL Revision list">Option A - Neurobiology SL Revision list</a></li><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23831/option-a-neurobiology-hl-revision-list.html" title="Option A - Neurobiology HL Revision list">Option A - Neurobiology HL Revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19001/option-c-ecology-revision-activities.html" title="Option C - Ecology revision activities">Option C - Ecology revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../27865/option-c-ecology-sl-revision-list-.html" title="Option C - Ecology SL revision list ">Option C - Ecology SL revision list </a></li><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../27863/option-c-ecology-hl-revision-list.html" title="Option C - Ecology HL revision list">Option C - Ecology HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa 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<div id="main-column" class="span9"> <article id="mitotic-index-cancer" style="margin-top: 16px;">
<h1 class="section-title">Mitotic index & cancer</h1>
<ul class="breadcrumb"><li><a title="Home" href="../../../biology.html"><i class="fa fa-home"></i></a><span class="divider">/</span></li><li><span class="gray">SL Core </span><span class="divider">/</span></li><li><span class="gray">Cells: Activities for Learning </span><span class="divider">/</span></li><li><span class="active">Mitotic index & cancer</span></li></ul>
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<p><img alt="" class="Left" src="../../../ib/biology/images/flickr_cc_commercial_ok/cells_dividing.jpeg" style="height: 80px; width: 100px; float: left;">In this activity students are first guided through the identification of cells in the different stages of mitosis. Following this, the next task is to count and record the number of cells undergoing mitosis and those which aren't in samples from human breast tissue biopsies. The calculation of the mitotic index is carried out and the results used as a prognostic tool to decide the nature of cells in the samples.</p><hr class="hidden"><div class="greyBg"><h3>Lesson Description</h3><div class="blueBg"><h3><a href="../../../ib/biology/images/flickr_cc_commercial_ok/cells_dividing.jpeg" target="_blank"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/cells_dividing.jpeg" style="float: right; width: 250px; height: 200px;"></a>Guiding Questions</h3><p>How long does it take a cell to divide?</p><p>Is mitosis more rapid in cancer cells than 'normal' cells?</p><p>Is interphase shorter in the cell cycle of cancer cells?</p></div><hr class="hidden"><h3>Activity 1- Identify the stages of mitosis in human cells</h3><p>The stages of mitosis in theoretical diagrams of chromosomes are often used to explain the process of mitosis. In real tissue samples the task is more challenging because the alignment of the spindle in metaphase and anaphase can be in any orientation. For example, two groups of dividing chromosomes in anaphase can be visible over the top of each other.</p><p>This illustration shows views of anaphase from different perspectives.</p><p style="text-align: center;"><a href="../../../ib/biology/images/flickr_cc_commercial_ok/perspectives_spindle_chromosomes.jpg" target="_blank"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/perspectives_spindle_chromosomes.jpg" style="width: 700px; height: 231px;"></a></p><p>Study the shapes of the nuclei in the images below and try to identify which phase of mitosis for each of the cells circled in green. Most of the cells surrounding these highlighted ones are in interphase.</p><p style="text-align: center; "><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/identifying-mitosis-in-tissue-slide_puzzle.png" style="width: 700px; height: 538px;"></p><hr class="hidden"><p>Complete the notes on the <a href="/media/ib/biology/files/activity%20worksheets/mitotic_identifying_mitosis_ss.pdf" target="_blank" title="Worksheets"><img class="ico" src="../../../img/icons/exercise.png"> Identifying the stages of mitosis student sheet.</a></p><p><iframe frameborder="0" height="480" scrolling="yes" src="/media/ib/biology/files/activity%20worksheets/mitotic_identifying_mitosis_ss.pdf" width="100%"></iframe></p><hr class="hidden"><h3>Activity 2: Calculate the mitotic index in two samples of human tissue</h3><p>A common test for tissue biopsies in cancer care uses visible features of the cells in the tissue. Different types of cancer each have a slightly different system. In breast cancer grading these features include:</p><ol><li>Tubule formation – how much the tissue has a normal structure (because cancer cells do not differentiate properly causing the tissue to lose it's normal structure).</li><li>Nuclear shape variations – cell nuclei look different from small round nuclei of normal cells (because some cancer genes cause changes in nuclear membrane shape and size).</li><li>The number of cells in one of the stages of mitosis (because cancer cells divide more frequently).</li></ol><p>The number of cells dividing is used to estimate the mitotic index in human tissue biopsies using the formula: </p><p style="text-align: center;"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/mitotic_index_formula.png" style="width: 400px; height: 93px;"></p><p>Calculation of the mitotic index of these cells in cancerous and normal tissues can help to decide how fast growing a cancer is, it can give a prognosis for the patient and help doctors and radiologists decide the best treatment to use.</p><p>The red, amber and green samples in the image below show the number of cells in a stage of mitosis (black arrows).<br>While the occurrence of mitosis is low in a single frame, ten microscope views at high power (x400) are often used to give better reliability, sometimes even more.</p><div class="blueBg"><p><strong>Method for calculation of the mitotic index:</strong></p><p style="text-align: center;"><a href="../../../ib/biology/images/flickr_cc_commercial_ok/quantifying-mitotic-index-in-three-slides_smaller.png" target="_blank"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/quantifying-mitotic-index-in-three-slides_smaller.png" style="width: 600px; height: 329px;"></a></p><ol><li>Identify any cells that are in any stage of mitosis. Use a red circle for each.</li><li>Count all the cells in the frame. <br>Put a dot on each nucleus, circle groups of ten cells, then count the number of groups, plus any remaining cells.</li></ol><p style="text-align: center;"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/mitosis_counting_cells.png" style="width: 200px; height: 165px;"></p><p style="margin-left:36.0pt;">Note: Identifying individual cells is not easy, as there is a variety of shapes and sizes of cells and even nuclei. Count quite quickly, without letting an occasional unclear cell slow down the process too much. Remember the cell count is an estimation and a total count of 145 or 146 will make little different to the mitotic index; 7/145 is almost the same as 7/146.</p><ol><li value="3">Record the number of cells in mitosis and the total number of cells.</li><li>Then calculate the mitotic index as a decimal and a %.</li></ol></div><p>Complete the calculations of mitotic index on this <a href="/media/ib/biology/files/activity%20worksheets/mitotic_index_two_samples_activity.pdf" target="_blank" title="Worksheets"><img class="ico" src="../../../img/icons/exercise.png"> Mitotic index activity with two samples</a> student worksheet.</p><p><iframe frameborder="0" height="420" scrolling="yes" src="/media/ib/biology/files/activity%20worksheets/mitotic_index_two_samples_activity.pdf" width="100%"></iframe></p><hr class="hidden"><h3>Activity 3 - Extension reading about cytokinesis</h3><p>Cytokinesis is essential to complete the cell cycle and divide a cell into two cells following mitosis. The details of the mechanisms are not required in detail for the IBDP Biology programme, but the way that it is different in plant and animal cells is required.</p><p>Read the following extract from the excellent cell biology text book, <a href="/media/ib/biology/files/activity%20worksheets/cytokinesis_reading_activity.pdf">Essential Cell Biology by Bruce Alberts, Karen Hopkin, Alexander D. Johnson, David Morgan and Martin Raff </a></p><p>As you read make a table of comparisons between cytokinesis in plant and animal cells</p><p><iframe frameborder="0" height="420" scrolling="yes" src="/media/ib/biology/files/activity%20worksheets/cytokinesis_reading_activity.pdf" width="100%"></iframe></p></div><section class="tib-teacher-only" title="Teacher only"><img class="icon" readonly="true" src="../../../img/icons/teacher-only.svg" title="Teacher only"><div class="pinkBg"><h3>Teachers' notes</h3><p><strong>Activity 1</strong> <strong>Recognising mitosis</strong> - Students are first guided through the identification of cells in different stages of mitosis. It is important that students have a basic reference document for the stages of mitosis, as this activity builds on the simple and clear explanations of chromosome movements during mitosis.</p><p>The slide shows 12 different views of human cells performing mitosis taken from biopsy sample of breast tissue. It is normal that there is some doubt in the identification of these cells, real pathologists must also find this difficult.</p><p>Model answers can be found on this page: <a href="../42201/identifying-stages-of-mitosis-model-answers.html" title="SL Core » Cells: Activities for Learning » Mitotic index & cancer » Identifying stages of mitosis - model answers">Identifying stages of mitosis - model answers</a> (access to this page can be controlled in the Student access area) and in the slides on the model answers page I have sketched a diagram of each cell, to try to show the process of identification of the stage of mitosis. Of course, just like real pathologists, your intermretation may be different from mine, but the slides were originally identified in this research paper,<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082576" target="_blank"> </a><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082576" target="_blank">Evaluation of Mitotic Activity Index in Breast Cancer Using Whole Slide Digital Images</a><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082576" target="_blank">, </a><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082576" target="_blank"><span id="article-result-0-date">published 30 Dec 2013 </span> <span id="article-result-0-journal-name"> PLOS ONE</span></a></p><p>The student's worksheet asks the students to <strong>suggest </strong>an identification of the phase of mitosis. The command term suggest is used when there is an element of doubt about the interpretation of data, so this may be a good opportunity to alert students to this possible which doesn occur occasionally in IB DP Biology exams. It is also an opportunity to make a link to TOK, because the reliability of scientific data does depend on human interpretation.</p><p><strong>Activity 2 Mitotic index</strong> - Students use their understanding of mitosis in cell tissue to estimate the Mitotic index. Hospitals use this index together with other qualitative data to grade cancer tissue from biopsies. There are two sets of five slides for students to identify cells undergoing mitosis. The method can be projected from the page, and the worksheet used to record the notes. Counting the cells is a bit of an art, and it may be worth explaining that this is an estimation. There are a few questions in this sheet which illustrate the use of the mitotic index as a prognostic tool, as a histologist or a doctor might do.</p><p>To estimate the mitotic index.</p><ul><li>Count the cells in each of the slides individually and record the numbers in the table on the worksheet.</li><li>For increased reliability add together the totals for cells A to E - these cells are all from one sample,</li><li>Cells F to J are from a second sample so repeat the calculation for these cells.</li></ul><p><strong>Activity 3 - Extension reading.</strong></p><p>The IB Bio guide mentions cytokinesis and this whole activity has looked at mitosis without a mention of cytokinesis. This reading puts this right. Although the text is from a university text book the details are all related to organelles in the cell and the differences between plant and animal cells. This is a great link back to cell structure and one of the key differences between plant and animal eukaryotic cells.</p><p>Students are asked to make a table showing comparisons between plant and animal cytokinesis. This activity will hep students to record useful notes from the reading, without having to write an essay!</p><p><strong>Alternative ideas </strong></p><p>Some classes may wish to try the technique on prepared slides of onion or garlic root tip cells as an extension activity.<br>If a wet lab is also wanted there are some good resources <a href="http://www.nuffieldfoundation.org/practical-biology/investigating-mitosis-allium-root-tip-squash" target="_blank">Mitotic index experiments on this website.</a></p><p>These ideas look great for building models to illustrate the cell cycle and mitosis. Cell cycle on a plate, and using wool in mitosis diagrams. (Images borrowed from <a href="https://mrsstevenschemistryclasses.blogspot.com/2018/11/apologia-biology-cells-cell-cycle-and.html" target="_blank">Mrs Stevens' Science classes blog </a>)<br><a href="https://mrsstevenschemistryclasses.blogspot.com/2018/11/apologia-biology-cells-cell-cycle-and.html" target="_blank"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/expt_mitosis_cell_cycle_ideas.png" style="width: 600px; height: 117px;"></a></p><p><strong>Onion or Garlic root tip experiments</strong></p><p><img alt="" class="Left" src="../../../ib/biology/images/Mitosis.jpg" style="height: 88px; width: 120px; float: left;">The cells in an onion root can quite easily be used to calculate the mitotic index and this is a good learning exercise. The cell outline in plant cells is much clearer than it is in human cells. The onions, or garlic can be grown in the lab, <em>Allium </em>species is mentioned in the speciation section of genetics because they illustrate cases of speciation by polyploidy. However diagnosis of cancer in onion roots is one step further away from learning about the actual clinical value of the mitotic index.</p><p>Legacy link to the old student worksheet <a href="/media/ib/biology/files/activity%20worksheets/mitotic_index_activity.pdf" target="_blank" title="Worksheets"><img class="ico" src="../../../img/icons/exercise.png"> Cancer and the cell cycle - student worksheet</a> <br>and the <span><a class="hover" href="../18364/mitotic-index-model-answers.html" title="New Guide - first exams 2016 » SL Core » Cells: Activities for Learning » Mitotic index & cancer » Mitotic index - model answers">Mitotic index worksheet - model answers for the two conclusion questions</a></span></p></div></section><script>document.querySelectorAll('.tib-teacher-only').forEach(e => e.remove());</script>
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